Perfluorobutanoic Acid (PFBA)

CASRN 375-22-4

External Peer Review Activities for PFBA Integrated Risk Information System (IRIS) Assessment (Nov 2021)


Meeting Objective

To facilitate the independent external peer review of the draft PFAS IRIS assessments, EPA has contracted with Eastern Research Group, Inc. (ERG). This website serves as a resource for upcoming peer review activities.

To help address this complex issue, the U.S. Environmental Protection Agency (EPA) is taking a proactive approach. Specifically, the development of human health toxicity assessments for exposure to individual PFAS represents only one component of the broader PFAS action plan underway at the EPA. The five Integrated Risk Information System (IRIS) toxicity assessments are being developed according to the scope and methods outlined in the systematic review protocol building upon several other PFAS assessments that have already been developed.

Panel Formation Process


Dahnish Shams,  Ph:  202-564-2758,  Email:

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Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic (man-made) chemicals widely used in consumer products and industrial processes. The basic structure of PFAS consists of a carbon chain surrounded by fluorine atoms, with different chemicals possessing different end groups; thousands of distinct PFAS exist in commerce.


Date Description
Nov 2019EPA released the Systematic Review Protocol for the PFAS IRIS Assessments (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]
Jul 2020EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.
Aug 2020EPA sent an interagency science consultation PFBA draft for review and comment.
Aug 2021EPA released the draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid for a 60-day public comment period and external peer review. Additionally, EPA announced the solicitation for the nominations of members to a PFAS IRIS Review Panel that will review all five assessments. [Federal Register Notice Aug 23, 2021]
Oct 2021EPA announced the external peer review meeting website and list of candidates (LoC) for the peer review panel.

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