Perfluorobutanoic Acid (PFBA)
CASRN 375-22-4
External Peer Review Activities for PFBA Integrated Risk Information System (IRIS) Assessment (Nov 2021)
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Overview
Meeting Objective
To facilitate the independent external peer review of the draft PFAS IRIS assessments, EPA contracted with ERG for the meeting. This website serves as a resource for the peer review activities associated with the draft IRIS assessment of PFBA. Per- and polyfluoroalkyl substances (PFAS) are a large class of man-made chemicals widely used in consumer products and industrial processes. The basic structure of PFAS consists of a carbon chain surrounded by fluorine atoms, with different chemicals possessing different end groups. EPA is developing five IRIS toxicity assessments including the IRIS assessment of PFBA according to the scope and methods outlined in the publicly posted systematic review protocol which builds upon several other PFAS assessments that have already been developed, and represent only one component of the broader PFAS action plan underway at the U.S. EPA.
Dates and Meeting Registration
- The meeting was held on February 22-23, 2022.
Members of the public were invited to attend as observers, by visiting the ERG PFBA Peer Review Zoom Meeting Registration page to attend.
A limited amount of time was set aside for oral public comment near the beginning of the peer review meeting on Feb 22nd. Requests to make oral statements were accommodated on a first-come, first-served basis, and ERG may have limited the amount of time for each speaker as well as the number of speakers due to time constraints.
Contact ERF with any questions regarding the peer review at: laurie.waite@erg.com (subject line: PFBA Peer Review Meeting).
- Elaine M. Faustman, Ph.D., DABT; Professor, School of Public Health, University of Washington (Panel Chair)
- Jeffrey W. Fisher, Ph.D.; Senior Research Fellow, ScitoVation
- Panagiotis G. Georgopoulos, Ph.D.; Professor, Rutgers University
- Joseph T. Haney, Jr., M.S.; Distinguished Toxicologist, Texas Commission on Environmental Quality (TCEQ)
- Alan M. Hoberman, Ph.D., DABT; President, Argus International, Inc.
- David A. Savitz, Ph.D.; Professor, Brown University
- R. Thomas Zoeller, Ph.D.; Professor Emeritus, University of Massachusetts Amherst
Panel Formation Process
- Federal Register Notice: Request for Nominations of Experts for the Review of EPA's Draft Toxicological Reviews of Perfluorodecanoic Acid (PFDA), Perfluorononanoic Acid (PFNA), Perfluorohexanoic Acid (PFHxA), Perfluorohexanesulfonic acid (PFHxS), and Perfluorobutanoic acid (PFBA)
- List of Candidates for IRIS PFAS Peer Review
- For more information specific to this peer review, please contact the ERG, Inc. at peerreview@erg.com (subject line: EPA PFAS assessments peer review).
Background
Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic (man-made) chemicals widely used in consumer products and industrial processes. The basic structure of PFAS consists of a carbon chain surrounded by fluorine atoms, with different chemicals possessing different end groups; thousands of distinct PFAS exist in commerce.
History/Chronology
| Date | Description |
|---|---|
| Nov 2019 | EPA released the Systematic Review Protocol for the PFAS IRIS Assessments (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019] |
| Jul 2020 | EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. |
| Aug 2020 | EPA sent an interagency science consultation PFBA draft for review and comment. |
| Aug 2021 | EPA released the draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid for a 60-day public comment period and external peer review. Additionally, EPA announced the solicitation for the nominations of members to a PFAS IRIS Review Panel that will review all five assessments. [Federal Register Notice Aug 23, 2021] |
| Oct 2021 | EPA announced the external peer review meeting website and list of candidates (LoC) for the peer review panel. |
| Feb 2022 | ERG, a contractor to EPA, hosted an independent public peer review meeting from February 22-23, 2022, to discuss the review of the IRIS assessment of PFBA and related salts. |
| Jun 2022 | ERG, a contractor to EPA, submitted their final peer review report to EPA on the review of the IRIS assessment of PFBA and related salts. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- List of Candidate for the Review of EPA IRIS Toxicilogical Review of the Pfas Chemicial Assessments (PDF) (14 pp, 234 KB, about PDF)
- EPA and ERG Agenda and Slides from the PFBA External Peer Review Meeting (Feb 2022) (PDF) (62 pp, 2 MB, about PDF)
- EPA Presentation on the Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (External Peer Review Meeting, May 2022) (PDF) (62 pp, 2 MB, about PDF)
- External Panel Peer Review of EPA's Draft "IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts" Final Peer Review Report" (PDF) (107 pp, 1 MB, about PDF)
- Docket No: EPA-HQ-ORD-2020-0675
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Related Link(s)
- Systematic Review Protocol for the Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid IRIS Assessment (Preliminary Assessment Materials, 2019)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Public Comment and External Review Draft, 2021)