US EPA

In April 2021, EPA released the Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols communicate the rationale for conducting the assessment of vanadium and compounds (oral), describe screening criteria to identify relevant literature, outline the approach for evaluating study quality, and describe the dose-response methods.

U.S. EPA. Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-21/047, 2021.

Vanadium is a naturally occurring metal that is the 22nd most abundant element in the earth’s crust and is found in a variety of minerals and nearly all coal and petroleum crude oils. Oral exposure to vanadium may occur naturally (e.g., foods) or anthropogenically via contamination of soil, surface waters, or groundwater.

Date	Description
01-Jul 2020	EPA released the IRIS Assessment Plan for oral exposure to vanadium and compounds for public comment and review. [Federal Register Notice Jul 24, 2020]
02-Apr 2021	EPA released the Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment for public comment and review. [Federal Register Notice Apr 26, 2021]

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials) (PDF)  (168 pp, 3 MB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

• Health Effects Assessment for Vanadium and Compounds
• IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft, 2012)
• IRIS Assessment Plan for Oral Exposure to Vanadium and Compounds (Scoping and Problem Formulation Materials)
• Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials)

• FR Notice: Apr 26, 2021

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2020-0183