US EPA

In July 2020, EPA released the draft IRIS Assessment Plan (IAP) for Oral Exposure to Vanadium and Compounds for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure and outcome measures. The IAP serves to inform the subsequent development of the chemical specific systematic review protocol.

U.S. EPA. IRIS Assessment Plan for Oral Exposure to Vanadium and Compounds (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-20/112, 2020.

Vanadium is a naturally occurring metal that is the 22nd most abundant element in the earth’s crust and is found in a variety of minerals and nearly all coal and petroleum crude oils. Oral exposure to vanadium may occur naturally (e.g., foods) or anthropogenically via contamination of soil, surface waters, or groundwater.

Date	Description
01-Jul 2020	EPA released the IRIS Assessment Plan for oral exposure to vanadium and compounds for public comment and review. [Federal Register Notice Jul 24, 2020]

Following the public (webinar) meeting, the IRIS Program will use the IAP to inform the subsequent development of a chemical-specific systematic review protocol.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Assessment Plan for Oral Exposure of Vanadium and Compounds (Scoping and Problem Formulation Materials) (PDF)  (57 pp, 2 MB, about PDF)

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• EPA-HQ-ORD-2020-0183
• Health Effects Assessment for Vanadium and Compounds
• IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft, 2012)
• Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials)
• IRIS Assessment Plan for Inhalation Exposure to Vanadium and Compounds (Scoping and Problem Formulation Materials)

• Literature Search References Sorted By Author (Vanadium)

• FR Notice: Aug 20, 2020
• FR Notice: Jul 24, 2020