IRIS

Perfluorohexanesulfonate (PFHxS)

CASRN 355-46-4

  • Status: Perfluorohexanesulfonate (PFHxS) is in step 1 at this time.

Systematic Review Protocol for the Perfluorohexanesulfonate (PFHxS) IRIS Assessment (Preliminary Assessment Materials)

Overview

In November 2019, EPA released the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments for a 45-day public comment period. As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

Citation

U.S. EPA. Systematic Review Protocol for the Perfluorohexanesulfonate (PFHxS) IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-19/050, 2019.

Contact

Andrew D. Kraft,  Ph:  202-564-0286,  Email: kraft.andrew@epa.gov

James W. Avery,  Ph:  202-564-1494,  Email: avery.james@epa.gov

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Background

This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

The IRIS Program posts assessment protocols and protocol updates publicly on a chemical’s HERO project page, the IRIS website, and in systematic review repositories such as Zenodo (https://zenodo.org/record/2654896#.XMsScOhKjcs).

History/Chronology

Date Description
Nov 2019EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]

Status

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.


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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Federal Register Notices

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2019-0275

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