IRIS

Chromium(VI)

CASRN 18540-29-9

Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials)

Notice

EPA announces the availability of the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) for a 45-day public comment period. EPA also announces a public science meeting (via webinar) scheduled for April 24, 2019.

Overview

In March 2019, EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

Citation

U.S. EPA. Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/155, 2019.

Contact

Catherine Gibbons,  Ph:  202-564-5431,  Email: gibbons.catherine@epa.gov

Alan F. Sasso,  Ph:  202-564-2608,  Email: sasso.alan@epa.gov

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Background

This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

History/Chronology

Date Description
Apr 2014EPA released preliminary meeting materials for chromium (VI), part 1, in preparation for the June 2014 Bimonthly Public Science Meeting.
Jun 2014EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 1.
Aug 2014EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting.
Oct 2014EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 2.
Mar 2019EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Mar 15, 2019]
Apr 2019EPA announced that they will host a public science meeting on April 24, 2019 (by webinar) to discuss the draft document.

Status

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.


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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Federal Register Notices

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2014-0313

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