CASRN 100-41-4

Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials)


EPA announced the release of the Protocol for the Ethylbenzene IRIS Assessment for a 30-day public comment period as announced in a February 17, 2023 Federal Register Notice. The deadline for comments was March 17, 2023.


In February 2023, EPA released the Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) for a 30-day public review and comment period. As part of developing a draft IRIS assessment, EPA presents a protocol that describes the methodology for how the assessment will be conducted, including systematic review and dose-response. These could include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.


U.S. EPA. Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-23/014, 2023.

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Ethylbenzene is a colorless, flammable liquid with a sweet, gasoline-like odor. It is naturally found in products such as coal tar and crude petroleum. Ethylbenzene is primarily used as a chemical intermediate to produce styrene. In smaller quantities, ethylbenzene is also used as a solvent in common products like rubber, inks, insecticides, paints, and in fuels.


Date Description
01-Sep 2017EPA released the IRIS Assessment Plan (IAP) for Ethylbenzene for public comment and review. [Federal Register Notice Sep 18, 2017]
02-Feb 2023EPA released the Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice February 17, 2023]


The IRIS Program will use the protocol to develop the draft assessment.

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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Federal Register Notices


Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2014-0526

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