IRIS Assessment Plan for Naphthalene (Scoping and Problem Formulation Materials)
U.S. EPA. IRIS Assessment Plan for Naphthalene (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/007, 2018.
Erin Yost, Ph: 919-541-3906, Email: firstname.lastname@example.org
Ingrid Druwe, Ph: 919-541-2452, Email: email@example.com
Naphthalene (CAS no. 91-20-3) is a bicyclic aromatic hydrocarbon with the chemical formula C10H8 and a molecular weight of 128.16. Pure naphthalene is a white, water-insoluble solid at room temperature with a vapor pressure of 0.087 mmHg (U.S. EPA, 1987; ATSDR,1993). Naphthalene is produced by distillation and fractionation of either petroleum or coal tar.
Naphthalene’s principal use is as an intermediate in the production of phthalic anhydride. Phthalic anhydride is important in the manufacturing of phthalate plasticizers, resins, dyes as well as insect and animal repellents. Naphthalene is also used in the manufacture of synthetic leather tanning agents and the insecticide carbaryl. Naphthalene has been used as a moth repellent and as a deodorizer for diaper pails and toilets (ATSDR, 1993; U.S. EPA, 1980, 1987).
|Jul 2018||EPA released the IRIS Assessment Plan of Naphthalene (Scoping and Problem Formulation) for a 30-day public comment period. An August 23, 2018 IRIS Public Science Webinar to discuss the document was also announced. [Federal Register Notice Jul 5, 2018]|
|Jul 2014||EPA released the IRIS Toxicological Review of Naphthalene (Scoping and Problem Formulation Materials) for discussion at a public science meeting held on September 3-4, 2014 to provide the opportunity for the public to give input on the developing draft assessment.|
|Aug 2005||EPA released the document Research Needs Related to Naphthalene Assessment summary report from the workshop.|
|Apr 2005||EPA hosted a Peer Consultation Workshop on research needs related to the mode of action of inhalation carcinogenicity on April 7, 2005.|
|Jul 2004||EPA released a revised IRIS Summary and Toxicological Review of Naphthalene (External Review Draft) for public comment and hosted an peer review panel meeting.|
|Aug 1998||EPA revised the IRIS Summary and Toxicological Review of Naphthalene and released an external review draft for public comment.|
The IRIS Program will use the IAP to inform the subsequent development of a chemical-specific systematic review protocol.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (23 pp, 429 KB, about PDF)
- Summary Review of Health Effects Associated with Naphthalene: Health Issue Assessment (1987)
- IRIS Toxicological Review of Naphthalene (1998 Final)
- IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update)
- Final Report from the External Peer Review of the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene (2004)
- Research Needs Related to Naphthalene Assessment (2005, Workshop)
- IRIS Toxicological Review of Naphthalene (2014, Scoping and Problem Formulation Materials)
Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2014-0527