IRIS

Chloroform

CASRN 67-66-3

Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials)

Notice

EPA announces the availability of the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) for a 30-day public comment period. Information regarding the implementation of systematic review in the IRIS Program is described in a January 2018 Memo.

Overview

In January 2018, EPA released the Systematic Review Protocol for the Chloroform IRIS Assessment (Inhalation). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

Citation

U.S. EPA. Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/486, 2018.

Contact

Ted Berner,  Ph:  202-564-7712,  Email: berner.ted@epa.gov

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Background

Chloroform (trichloromethane) is a colorless, volatile liquid with a distinct odor. Chloroform is nonflammable. It is slightly soluble in water and is readily miscible with most organic solvents. Because chloroform is relatively volatile, it tends to escape from contaminated environmental media (e.g., water or soil) into air, and may also be released in vapor form from some types of industrial or chemical operations.

Therefore, humans may be exposed to chloroform not only by ingestion of chloroform in drinking water, food, or soil, but also by dermal contact with contaminated media (especially water) and by inhalation of vapor (especially in indoor air).

History/Chronology

Date Description
Sep 1984EPA released the Health Effects Assessment for Chloroform.
Apr 1988EPA released the Updated Health Effects Assessment for Chloroform.
Oct 2001EPA released the final toxicological report and summary document and posted these to the IRIS database.
Sep 2017EPA released the IRIS Assessment Plan (IAP) for Chloroform for public comment and review. [Federal Register Notice Sep 18, 2017]
Sep 2017EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) discussed the draft document at a public meeting on September 27-28, 2017.
Jan 2018EPA released the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). [Federal Register Notice Jan 31, 2018]

Status

The IRIS Program will use the systematic review protocol to develop the draft assessment.


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