Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials)
U.S. EPA. Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/486, 2018.
Ted Berner, Ph: 202-564-7712, Email: firstname.lastname@example.org
Chloroform (trichloromethane) is a colorless, volatile liquid with a distinct odor. Chloroform is nonflammable. It is slightly soluble in water and is readily miscible with most organic solvents. Because chloroform is relatively volatile, it tends to escape from contaminated environmental media (e.g., water or soil) into air, and may also be released in vapor form from some types of industrial or chemical operations.
Therefore, humans may be exposed to chloroform not only by ingestion of chloroform in drinking water, food, or soil, but also by dermal contact with contaminated media (especially water) and by inhalation of vapor (especially in indoor air).
|Sep 1984||EPA released the Health Effects Assessment for Chloroform.|
|Apr 1988||EPA released the Updated Health Effects Assessment for Chloroform.|
|Oct 2001||EPA released the final toxicological report and summary document and posted these to the IRIS database.|
|Sep 2017||EPA released the IRIS Assessment Plan (IAP) for Chloroform for public comment and review. [Federal Register Notice Sep 18, 2017]|
|Sep 2017||EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) discussed the draft document at a public meeting on September 27-28, 2017.|
|Jan 2018||EPA released the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). [Federal Register Notice Jan 31, 2018]|
The IRIS Program will use the systematic review protocol to develop the draft assessment.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
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