IRIS

Nitrate

CASRN 14797-55-8

IRIS Assessment Plan for Nitrate and Nitrite (Scoping and Problem Formulation Materials)

Notice

EPA announces the release of the draft IRIS Assessment Plan for Nitrate and Nitrite for public comment. This document will be discussed at an EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) meeting on September 27-28, 2017. Information regarding the meeting can be found on the SAB website.

Overview

In September 2017, EPA released the draft IRIS Assessment Plan (IAP) for Nitrate and Nitrite for public review and comment. This document was discussed at an EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) meeting on September 27-28, 2017. The IAP communicates to the public the plan for accessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation, objectives and specific aims for the assessment, and a PECO (Populations, Exposures, Comparators, and Outcomes) framework that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.

Citation

U.S. EPA. IRIS Assessment Plan for Nitrate and Nitrite (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/331, 2017.

Contact

Larissa Pardo,  Email: pardo.larissa@epa.gov

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Background

Nitrate (NO3−) and nitrite (NO2−), naturally occurring anions in the environment, play an essential role in Earth’s nitrogen cycle. Since 1950, human sources of nitrogen have increased substantially, creating a global surplus of nitrate/nitrite that supersedes natural sources by about 30%. Nitrate salts are mainly used as nitrogen fertilizers and in industrial explosives, fireworks, and glass making, whereas nitrites are largely used as preservatives for meat and fish curing and as color fixatives.

History/Chronology

Date Description
Sep 2017EPA released the IRIS Assessment Plan (IAP) for Nitrate and Nitrite for public comment and review. [Federal Register Notice Sep 18, 2017]

Status

Following the SAB public meeting, the IRIS Program will use the IAP to inform the subsequent development of chemical-specific systematic review protocols.


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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Federal Register Notices

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2017-0496

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