CASRN 67-66-3

IRIS Assessment Plan for Chloroform (Scoping and Problem Formulation Materials)

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In September 2017, EPA released the draft IRIS Assessment Plan (IAP) for Chloroform for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.


U.S. EPA. IRIS Assessment Plan for Chloroform (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/330, 2017.

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Chloroform (trichloromethane) is a colorless, volatile liquid with a distinct odor. Chloroform is nonflammable. It is slightly soluble in water and is readily miscible with most organic solvents. Because chloroform is relatively volatile, it tends to escape from contaminated environmental media (e.g., water or soil) into air, and may also be released in vapor form from some types of industrial or chemical operations.

Therefore, humans may be exposed to chloroform not only by ingestion of chloroform in drinking water, food, or soil, but also by dermal contact with contaminated media (especially water) and by inhalation of vapor (especially in indoor air).


Date Description
01-Sep 1984EPA released the Health Effects Assessment for Chloroform.
02-Apr 1988EPA released the Updated Health Effects Assessment for Chloroform.
03-Oct 2001EPA released the final toxicological report and summary document and posted these to the IRIS database.
04-Sep 2017EPA released the IRIS Assessment Plan (IAP) for Chloroform for public comment and review. [Federal Register Notice Sep 18, 2017]
05-Sep 2017EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) discussed the draft document at a public meeting on September 27-28, 2017.


Following the SAB public meeting, the IRIS Program will use the IAP to inform the subsequent development of chemical-specific systematic review protocols.

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