CASRN 100-41-4

IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials)


In September 2017, EPA released the draft IRIS Assessment Plan (IAP) for Ethylbenzene for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.


U.S. EPA. IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/332, 2017.

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Ethylbenzene, also known as phenylethane, is an aromatic hydrocarbon that is present in crude petroleum and gasoline. In addition, it is used in industry primarily as a chemical intermediate in the production of styrene monomer. Ethylbenzene has also been used as an industrial solvent and as a diluent in the paint industry as well as in the manufacture of synthetic rubber, acetophenone, and cellulose acetate. Ethylbenzene is present in naphtha, asphalt, and as an impurity in xylene solvents.


Date Description
01-Sep 2017EPA released the IRIS Assessment Plan (IAP) for Ethylbenzene for public comment and review. [Federal Register Notice Sep 18, 2017]
02-Sep 2017EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) held a meeting on September 27-28, 2017 to discuss the assessment. Information regarding the meeting can be found on the SAB website.
03-Apr 2019EPA suspended the assessment in fiscal year 2019. It may be restarted as Agency priorities change.
04-Jun 2021This assessments was unsuspended and included in the June 2021 IRIS Program Outlook as a chemical back under development.

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