CASRN 75-65-0

  • Status: Tert-Butanol is in step 4 at this time.

IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (External Review Draft)


EPA is announcing the availability of the draft report, IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (External Review Draft), as announced in the Jun 16, 2017 Federal Register Notice. This FRN invites the public to comment on the draft report prior to the public peer review meeting.


The IRIS Toxicological Review of tert-Butyl Alcohol (tert-Butanol) was released for external peer review in June 2017. EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the tert-butanol assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website.


U.S. EPA. IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/015, 2017.


Janice S. Lee,  Ph:  919-541-9458,  Email:

Keith Salazar,  Ph:  202-564-0441,  Email:

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tert-butyl Alcohol (tert-butanol) is used as a solvent; as a denaturant for ethanol and several other alcohols; in the manufacture of flotation agents, fruit essences, and perfumes; as an octane booster in gasoline; as a dehydrating agent; and as a chemical intermediate in the manufacture of methyl methacrylate. tert-Butanol's production for industrial uses may result in its direct release to the environment through various waste streams. tert-Butanol is also a likely degradation product of methyl tert-butyl ether (MTBE) and ethyl tertiary butyl ether (ETBE). Probable routes of human exposure to tert-butanol include inhalation, ingestion, and skin or eye contact.


Date Description
Aug 2013EPA released preliminary assessment materials (draft literature searches and associated search strategies, evidence tables and exposure response arrays) for discussion at an IRIS Public Science Meeting.
Dec 2013EPA discussed tert-butanol at the December 2013 IRIS public science meeting.
Sep 2014EPA sent an interagency science consultation draft for review and comment.
May 2016EPA released the public comment draft for public review and comment.
Jun 2016EPA convened a public science meeting June 29-30, 2016 to discuss the public comment draft.
Jun 2017EPA released the external review draft and charge to reviewers prior to the public peer review meeting.[SAB FR Notice Jun 16, 2017]


Following external peer review, the assessment will be revised. The assessment will then undergo a final EPA internal review and a review by other federal agencies and the Executive Office of the President. Once final, the assessment will be posted to the IRIS database.

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