Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
CASRN 121-82-4
IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft)
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Overview
Citation
U.S. EPA. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/302, 2014.
Background
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX, or Royal Demolition eXplosive) is a military explosive with limited civilian uses. In the United States, RDX is produced at Army ammunition plants; it is not produced commercially.
An oral reference dose (RfD) and an oral cancer slope factor are currently available on IRIS. A reassessment of the human health effects of RDX, including both cancer effects and effects other than cancer, is being undertaken.
History/Chronology
Date | Description |
---|---|
Aug 2013 | EPA released preliminary draft materials for discussion at the December IRIS Bimonthly Public Meeting. |
Dec 2013 | EPA discussed preliminary draft materials at the December 12-13, 2013 IRIS Bimonthly Public Meeting. Presentations are also available on the meeting web site. |
Sep 2014 | EPA initiated the interagency science consultation on the draft Toxicological Review of RDX. |
Mar 2016 | EPA released the public comment draft for a 60-day review period and announced it will be discussed at the May 10, 2016 IRIS Public Science Meeting. EPA also released the interagency science consultation documents, comments from reviewers, and EPA's response to major comments. [Federal Register Notice: Mar 10, 2016] |
Status
The hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) IRIS assessment was released for public comment in March 2016. Following the public comment period, the assessment will be revised taking into consideration public comments. The assessment will then be released for external peer review.
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) Interagency Consultation Draft (PDF) (160 pp, 2 MB, about PDF)
- Supplemental Information for the IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) Interagency Consultation Draft (PDF) (128 pp, 2 MB, about PDF)
- Charge to Reviewers Sep 2014 (PDF) (3 pp, 111 KB, about PDF)
- EPA Response to Major Interagency Comments (PDF) (7 pp, 193 KB, about PDF)
- 1. CDC/ATSDR Comments on the RDX Interagency Consultation Draft (PDF) (2 pp, 122 KB, about PDF)
- 2. CEQ Comments on the RDX Interagency Consultation Draft (PDF) (1 pp, 64 KB, about PDF)
- 3. DoD Comments on the RDX Interagency Consultation Draft (PDF) (18 pp, 177 KB, about PDF)
- 4. DoD Comments on the RDX Interagency Consultation Draft (Supplemental Information Document) (PDF) (4 pp, 77 KB, about PDF)
- 5. DoD Comments on the RDX Interagency Consultation Draft (Charge) (PDF) (4 pp, 89 KB, about PDF)
- 6. NASA Comments on the RDX Interagency Consultation Draft (PDF) (1 pp, 61 KB, about PDF)
- 7. NIOSH Comments on the RDX Interagency Consultation Draft (PDF) (1 pp, 112 KB, about PDF)
- 8. NTP Comments on the RDX Interagency Consultation Draft (PDF) (4 pp, 95 KB, about PDF)
- 9. OMB and OSTP Comments on the RDX Interagency Consultation Draft (PDF) (5 pp, 147 KB, about PDF)
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Related Link(s)
- IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Preliminary Assessment Materials)
- IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Public Comment Draft)
- IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (External Review Draft)