tert-Butyl Alcohol (tBA)
CASRN 75-65-0
IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Interagency Science Consultation Draft, 2014)
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Overview
Citation
U.S. EPA. IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Interagency Science Consultation Draft, 2014). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/378, 2014.
Background
Tert-butyl alcohol (tert-butanol) is used as a solvent; as a denaturant for ethanol and several other alcohols; in the manufacture of flotation agents, fruit essences, and perfumes; as an octane booster in gasoline; as a dehydrating agent; and as a chemical intermediate in the manufacture of methyl methacrylate. tert-Butanol's production for industrial uses may result in its direct release to the environment through various waste streams. tert-Butanol is also a likely degradation product of methyl tert-butyl ether (MTBE). Probable routes of human exposure to tert-butanol include inhalation, ingestion, and skin or eye contact.
History/Chronology
Date | Description |
---|---|
Aug 2013 | EPA released Preliminary Assessment Materials (draft literature searches and associated search strategies, evidence tables and exposure response arrays) in anticipation for discussion at an upcoming IRIS Public Science Meeting. |
Dec 2013 | EPA discussed tert-butanol at the December 2013 IRIS public science meeting. |
Sep 2014 | EPA sent an interagency science consultation draft for review and comment. |
May 2016 | EPA released the public comment draft for public review and comment. Additionally, the interagency science consultation draft, comments from reviewers, and EPA’s responses to selected major interagency comments were also released. |
Jun 2016 | EPA discussed the tBA (public comment draft) at the June 29-30, 2016 IRIS Public Science Meeting. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of tert-Butyl Alcohol (Interagency Science Consultation Review Draft) (PDF) (142 pp, 3 MB, about PDF)
- IRIS Toxicological Review of tert-Butyl Alcohol Supplementary Information (Interagency Science Consulation Draft) (PDF) (89 pp, 1 MB, about PDF)
- Charge to Reviewers (Interagency Science Consulation Draft) (PDF) (3 pp, 126 KB, about PDF)
- EPA's Response to Select Interagency Comments on the Assessment for tert-Butanol (PDF) (5 pp, 177 KB, about PDF)
- 1. OMB/OSTP tert-Butyl Alcohol IASC Comments Nov 2014 (PDF) (1 pp, 133 KB, about PDF)
- 2. NTP tert-Butyl Alcohol IASC Comments Nov 2014 (PDF) (3 pp, 231 KB, about PDF)
- IRIS Public Science Meeting (Dec 2013)
- IRIS Public Science Meeting (Jun 2016)
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