- IRIS Summary (PDF) (29 pp, 186 K)
- Workshop & meeting details from the development of the draft IRIS Assessment for inorganic arsenic
- Status: Arsenic, inorganic is in step 1 at this time.
IRIS Toxicological Review of Inorganic Arsenic (Preliminary Assessment Materials)
- Draft literature search strategies
- The approach for identifying studies
- The screening process for selecting pertinent studies
- The resulting list of pertinent studies
- Preliminary evidence tables
- The process for selecting studies to include in evidence tables
- The quality of the studies in the evidence tables
U.S. EPA. IRIS Toxicological Review of Inorganic Arsenic (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/630/R-14/101, 2014.
J. Allen Davis, Ph: 513-569-7024, Email: firstname.lastname@example.org
Janice S. Lee, Ph: 919-541-9458, Email: email@example.com
Inorganic arsenic is used for hardening copper and lead alloys. It also is used in glass manufacturing as a decolorizing and refining agent, as a component of electrical devices, in the semiconductor industry, and as a catalyst in the production of ethylene oxide. Arsenic compounds are used as a mordant in the textile industry, for preserving hides, as medicinals, pesticides, pigments, and wood preservatives.
Arsenic is also found naturally in the environment and is typically present in soil and water at detectable levels. Sources of human exposure to inorganic arsenic include drinking water, diet, air, and soils (which can contain naturally occurring arsenic or contamination from anthropogenic sources). This draft IRIS health assessment addresses cancer and non-cancer human health effects that may result from chronic exposure to this chemical.
|1988||EPA published the IRIS Health Hazard Assessment for Inorganic Arsenic.|
|1999||NRC reviewed the 1988 IRIS assessment and the available health data for inorganic arsenic and made recommendations for updating the cancer assessment in Arsenic in Drinking Water.|
|2001||NRC updated the NRC (1999) report and evaluated the toxicological risk and health effects of arsenic as relevant to the 2001 Arsenic Rule in Arsenic in Drinking Water – 2001 Update.|
|2001||NRC reviewed the 2001 Primary Drinking Water Standard for inorganic Arsenic and made recommendations for applying epidemiologic data in the cancer health assessment.|
|2003||EPA started a reassessment of the IRIS Toxicological Review.|
|2005||EPA released the draft IRIS inorganic arsenic assessment in July 2005 for public comment and peer review.|
|2007||Science Advisory Board (SAB) posted a response to the 2005 EPA reassessment of inorganic arsenic (cancer).|
|2008||Draft IRIS Toxicological Review for Inorganic Arsenic (cancer) submitted to OMB for interagency review.|
|2010||EPA released the revised draft IRIS inorganic arsenic assessment for public comment and peer review, SAB announced public teleconference to conduct a quality review of the draft report to be held on November 22, 2010. [Federal Register Oct 25, 2010], and SAB completed its review of the draft assessment.|
|2011||Congress directed EPA to contract with the National Research Council (NRC) to review the draft assessment.|
|Jan 2013||EPA held a public planning and scoping meeting for development of a new IRIS Toxicological Review of Inorganic Arsenic.|
|Mar 2013||EPA held eight science issues public webinars (Mar–July).|
|May 2013||EPA submitted a draft Assessment Development Plan (ADP) and preliminary assessment materials to NRC for review.|
|Nov 2013||NRC released the interim report, Critical Aspects of EPA’s IRIS Assessment of iAs and provided recommendations; NRC supported EPA’s plan.|
|Jun 2014||EPA held a public science meeting to present and encourage comments on the ADP, preliminary assessment materials, and key science issues.|
|Apr 2015||EPA released a revised ADP and other preliminary materials and held two public meetings (webinars).|
The draft document is scheduled to be reviewed by the National Academy of Sciences in 2018.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (731 pp, 8 MB, about PDF)
Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2012-0830