CASRN 100-41-4

IRIS Toxicological Review of Ethylbenzene (Scoping and Problem Formulation Materials)

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In July 2014, EPA released scoping and problem formulation materials for new IRIS assessments of ethylbenzene and naphthalene for public comment and discussion. The scoping information was based on input from EPA's program and regional offices and was provided for informational purposes.

During problem formulation, the IRIS Program was looking for input from the scientific community and the general public as it framed the specific scientific questions for the systematic reviews used to develop the assessments. These problem formulation materials were the first to be developed since the NRC released its Review of EPA's IRIS Process in May 2014. EPA followed these recommendations in developing the ethylbenzene and naphthalene problem formulations materials. Background information on the chemicals was also provided.

In order to facilitate a scientific discussion, EPA identified several key science questions that were a main focus of the meeting discussion.


U.S. EPA. IRIS Toxicological Review of Ethylbenzene (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/198, 2014.


Paul Reinhart,  Ph:  919-541-1456,  Email:

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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