IRIS

Chromium(VI)

CASRN 18540-29-9

IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials)

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Overview

In August 2014, EPA released the second part of draft literature searches and associated search strategies, evidence tables, and exposure response arrays for Cr(VI) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:
  • Draft literature search strategies
    • The approach for identifying studies
    • The screening process for selecting pertinent studies
    • The resulting list of pertinent studies
  • Preliminary evidence tables
    • The process for selecting studies to include in evidence tables
    • The quality of the studies in the evidence tables
The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

Citation

U.S. EPA. IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/218, 2014.

Contact

Catherine Gibbons,  Ph:  202-564-5431,  Email: gibbons.catherine@epa.gov

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History/Chronology

Date Description
April 2014EPA released preliminary meeting materials for chromium (VI) in preparation for the June 2014 Bimonthly Public Science Meeting.
Jun 2014EPA hosted a public science meeting to discuss preliminary literature materials.
Aug 2014EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting.
Oct 2014EPA hosted a public science meeting to discuss preliminary literature materials (part 2).

Additional Information

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2014-0313

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