Diethyl phthalate (DEP)
IRIS Toxicological Review of Diethyl Phthalate (DEP) (Preliminary Assessment Materials)
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- Draft literature search strategies
- The approach for identifying studies
- The screening process for selecting pertinent studies
- The resulting list of pertinent studies
- Preliminary evidence tables
- The process for selecting studies to include in evidence tables
- The quality of the studies in the evidence tables
U.S. EPA. IRIS Toxicological Review of Diethyl Phthalate (DEP) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-13/302, 2014.
James W. Avery, Ph: 202-564-1494, Email: email@example.com
DEP is a colorless liquid with slight aromatic odor. It is soluble in water and slightly volatile. Impurities in technical DEP include isophthalic acid, terephthalic acid and maleic anhydride at levels of less than 1%. The DEP molecule contains two “ester” chemical groups. Ester chemical groups are generally susceptible to being hydrolyzed by a number of biotic and abiotic processes. Cleaving one DEP ester group leads to the formation of a monoester (monethyl phthalate – MEP) and cleaving both ester groups produces the diacid metabolite/degradate, phthalic acid.
DEP is used to improve the performance and durability of a number of products. As a plasticizer, it is added to plastic polymers to help maintain flexibility. It has been used in a variety of products including plastic films, rubber, tape, toothbrushes, automotive components, tool handles and toys. In addition to plastics, DEP is present in a wide range of personal care products (e.g., cosmetics, perfume, hair spray, nail polish, soap, detergent, and lotions), industrial materials (e.g., rocket propellant, dyes, packaging, sealants and lubricants), and medical products (e.g., enteric coatings on tablets and in dental impression materials). Previous uses as an inert ingredient in pesticide formulations are no longer allowed in the U.S.
|Mar 2014||EPA released Preliminary Assessment Materials (draft literature searches and associated search strategies, evidence tables and exposure response arrays) in anticipation for discussion at an upcoming IRIS Public Science Meeting.|
|Apr 2014||EPA discussed DEP at the April 2014 IRIS public science meeting.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (129 pp, 2 MB, about PDF)