CASRN 75-65-0

  • Status: Tert-Butanol is in step 5 at this time.

IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (Public Comment Draft)

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EPA is developing an Integrated Risk Information System (IRIS) assessment of tert-butyl Alcohol (tert-butanol) and has released the public comment draft assessment for public comment and external peer review. When final, the assessment will appear on the IRIS database.


U.S. EPA. IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (Public Comment Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-16/079, 2016.


J. Andre Weaver,  Ph:  703-347-0194,  Email:

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tert-butyl Alcohol (tert-butanol) is used as a solvent; as a denaturant for ethanol and several other alcohols; in the manufacture of flotation agents, fruit essences, and perfumes; as an octane booster in gasoline; as a dehydrating agent; and as a chemical intermediate in the manufacture of methyl methacrylate. tert-Butanol's production for industrial uses may result in its direct release to the environment through various waste streams. tert-Butanol is also a likely degradation product of methyl tert-butyl ether (MTBE). Probable routes of human exposure to tert-butanol include inhalation, ingestion, and skin or eye contact.


Date Description
Aug 2013EPA released Preliminary Assessment Materials (draft literature searches and associated search strategies, evidence tables and exposure response arrays) for discussion at an IRIS Public Science Meeting.
Dec 2013EPA discussed tert-butanol at the December 2013 IRIS public science meeting.
Sep 2014EPA sent an interagency science consultation draft for review and comment.
May 2016EPA released the public comment draft for public review and comment. It is also a topic of discussion for the May 10, 2016 IRIS Public Science Meeting.


Following public comment and external peer review, the assessment will be revised taking into consideration peer review and public comments. The assessment will then undergo a final EPA internal review and a review by other federal agencies and the Executive Office of the President. Once final, the assessment will be posted to the IRIS database.

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