IRIS

Formaldehyde

CASRN 50-00-0

IRIS Toxicological Review of Formaldehyde-Inhalation (External Review Draft, 2022)

Notice

EPA announces the availability of the external review draft of the IRIS Toxicological Review of Formaldehyde-Inhalation for a 60-day public comment period as announced in the Federal Register. The deadline for comments is June 13, 2022. [FR Notice: Apr 14, 2022]

Overview

In April 2022, EPA publicly released the draft formaldehyde assessment for review and comment. The IRIS Toxicological Review of Formaldehyde-Inhalation provides the scientific support and rationale for the hazard and dose-response assessment of inhalation exposure to formaldehyde. Following public comment, the assessment will undergo an independent external scientific peer review managed by the National Academies of Sciences, Engineering, and Medicine (NASEM), under contract with EPA.

Citation

U.S. EPA. IRIS Toxicological Review of Formaldehyde-Inhalation (External Review Draft, 2022). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-22/039, 2022.

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Background

Formaldehyde is present in a variety of products including plywood adhesives, abrasive materials, insulation, pesticides, and embalming fluids. Major sources of anthropogenic emissions include household furnishings and building materials, motor vehicle exhaust, manufacturing plants that produce or use formaldehyde or substances that contain it (e.g., glues), and tobacco smoke.

History/Chronology

Date Description
11-May 2011NAS's Board on Environmental Studies and Toxicology (BEST) released the NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report).
12-Apr 2014EPA convened a state-of-the-science workshop on formaldehyde on April 30 and May 1, 2014 in Arlington, VA. This workshop focused on 3 themes, see the web site for specific details.
13-Jun 2018The IRIS Assessment of Formaldehyde (Inhalation) Agency Review draft (completed in 2017) is formally suspended.
15-Mar 2021EPA updates the list of priority assessments developed by IRIS. EPA unsuspends the IRIS Toxicological Review of Formaldehyde (Inhalation).
16-Dec 2021EPA initiated an interagency science consultation on the draft Toxicological Review of Formaldehyde (Inhalation).
17-Apr 2022EPA released the draft Toxicological Review of Formaldehyde-Inhalation (External Review Draft) for public comment and subsequent external peer review by the National Academies of Sciences, Engineering, and Medicine (NASEM). Also released was the EPA lead Interagency Science Consultation draft with interagency comments.


Status

The assessment is available for a 60-day public comment period. After the public comment period, the assessment will undergo an independent external scientific peer review managed by the National Academies of Sciences, Engineering, and Medicine (NASEM).


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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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Federal Register Notices

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2010-0396

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