CASRN 92-52-4

IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft)

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EPA is releasing the draft report, Toxicological Review of Biphenyl, that was distributed to other federal agencies and the Executive Office of the President for comment during Interagency Science Discussion (IASD) (Step 6b) of the IRIS assessment development process. Interagency comments received and EPA’s response are provided below.


U.S. EPA. IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/005D, 2013.


Samantha J. Jones,  Ph:  202-564-6794,  Email:

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Biphenyl is an organic compound that forms colorless crystals. It occurs naturally in coal tar, crude oil, and natural gas. Biphenyl was once used in the production of polychlorinated biphenyls (PCBs) before they were banned in the late 1970s. It is no longer used as an antimicrobial and a fungicide in the U.S., but it is still used as a fungistat in other countries, most commonly in the packaging of citrus fruits. Today, biphenyl is mainly used in the production of pesticides, as a dye carrier in polyester dyeing, and as a component of heat transfer fluids, which are used for industrial processing applications. Biphenyl is found at multiple Superfund sites and other hazardous waste sites. It is on the list of Hazardous Air Pollutants (HAPs) and is classified as one of the High Production Volume (HPV) chemicals.


Date Description
Aug 1989The RfD for Biphenyl was posted to the IRIS Database.
Mar 1991The cancer assessment for Biphenyl was posted to the IRIS database.
Jul 2011EPA hosted an interagency science consultation on the review of the draft Toxicological Review of Biphenyl.
Sep 2011EPA released the external review draft of the biphenyl assessment for public review and comment. [Federal Register Notice Sep 30, 2011]
Apr 2012The external peer review workshop was held.
Jun 2012EPA released the comments from the public comment period and external peer review workshop.
Apr 2013EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Biphenyl and IRIS Summary for Biphenyl.
Aug 2013EPA released the final IRIS Toxicological Review of Biphenyl and IRIS Summary for Biphenyl, along with the interagency science discussion draft, interagency comments, and EPA’s response to interagency comments.


This assessment has been loaded into the IRIS Website and Database.

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