CASRN 109-99-9

IRIS Toxicological Review of Tetrahydrofuran (THF) (Final Report)


EPA has released the Toxicological Review of Tetrahydrofuran: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.


U.S. EPA. IRIS Toxicological Review of Tetrahydrofuran (THF) (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/006F, 2012.


IRIS Hotline,  Ph:  202-566-1676,  Email:

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Date Description
Aug 2007EPA released the first External Review Draft for public review and comment.
Sep 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review of THF.
Feb 2012EPA released the final toxicological review and IRIS Summary for Tetrahydrofuran, along with the interagency science discussion draft, interagency comments, and EPA's response to major interagency comments.
Jun 2017EPA released an update to the final report, with an errata sheet explaining the corrections.

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This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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