IRIS

Urea

CASRN 57-13-6

IRIS Toxicological Review of Urea (Final Report)

Overview

EPA has finalized the Toxicological Review of Urea: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.

Citation

U.S. EPA. IRIS Toxicological Review of Urea (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/005F, 2011.

Contact

IRIS Hotline,  Ph:  202-566-1676,  Email: hotline.iris@epa.gov

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Background

Urea, also known as carbamide, is an endogenous product of protein and amino acid catabolism. It can also be produced synthetically by combining ammonia, carbon monoxide, and sulfur in methanol. Urea is utilized in diesel selective catalyst reduction, in fertilizers and animal feed, plastics, flame-proofing agents, adhesives, flavoring agents and consumer goods such as liquid soaps, detergents and household cleaning products.

History/Chronology

Date Description
Apr 2008The IRIS reassessment of urea was initiated as a draft development document.
Jun 2010EPA hosted the interagency science consultation on the draft Toxicological Review of Urea.
Sep 2010EPA released the External Review Draft for public review and comment and the interagency science consultation review draft with comments. [Federal Register Sep 28, 2010]
Nov 2010EPA announced the external peer review meeting to be held on December 13, 2010 via teleconference. [Federal Register Nov 10, 2010]
Jan 2011EPA released the comments from the public comment period and external review workshop.
Jun 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Urea.
Jul 2011EPA released the final Toxicological Review of Urea, IRIS Summary for Urea and the interagency review draft with interagency review comments.

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Download(s)

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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