CASRN 67-56-1

IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)

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EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.


U.S. EPA. IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/001A, 2011.


Jeffrey S. Gift,  Ph:  919-541-4828,  Email:

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Methanol is a high production volume chemical with many commercial uses. It is a basic building block for numerous chemicals. Many of its derivatives are used in the construction, housing or automotive industries. Consumer products that contain methanol include varnishes, shellacs, paints, windshield washer fluid, antifreeze, adhesives, and deicers. This draft IRIS health assessment addresses non-cancer human health effects that may result from chronic exposure to this chemical. This draft assessment provides an inhalation reference concentration (RfC) for chronic non-cancer health effects and a reassessment of the oral reference dose (RfD).


Date Description
Sep 1988EPA posted the assessment of an oral reference dose for methanol on the IRIS Database.
Jul 1993EPA revised the oral reference dose for methanol.
Dec 2009EPA hosted an interagency science consultation on the draft IRIS Toxicological Review of Methanol for cancer and non-cancer health effects.
Jan 2010EPA released the IRIS Toxicological Review of Methanol (External Review Draft) on cancer and non-cancer health effects for public review and comment, and announced the public listening session would be held on February 23, 2010. [Federal Register Jan 12, 2010]
Jun 2010Following a report from the National Toxicology Program, EPA placed on hold the draft Methanol Toxicological Review on cancer and non-cancer health effects (see June 15, 2010 press release).
Apr 2011EPA released the external review draft of the IRIS Toxicological Review of Methanol (Non-Cancer) for public review and comment. EPA also announced a public listening session to be held on May 26, 2011 in Arlington, VA. [Federal Register Apr 18, 2011]
Jun 2011EPA released a federal register notice announcing an addendum to the draft document, a 14-day public comment period for the addendum, and the details for an upcoming public workshop. [Federal Register Jun 22, 2011]
Oct 2011EPA releases the comments from the public comment period and external review workshop.
Mar 2012EPA announced that data from the Ramazzini Institute (Ramazzini update) on lymphomas and leukemias would not be used in IRIS assessments. This decision impacted the cancer assessment contained in the December 2009 draft methanol assessment, which was released in January 2010 for external peer review. The December 2009 draft assessment has been archived.


Following the External Peer Review, the final assessment will be published on the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2009-0398" (for the docket ID) to comment on this report.

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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