IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010)
Barbara Glenn, Ph: 202-343-9721, Email: email@example.com
Andrew D. Kraft, Email: firstname.lastname@example.org
UPDATE EPA is currently revising its Integrated Risk Information System (IRIS) assessment of formaldehyde to address the 2011 NAS peer review recommendations. This assessment addresses both noncancer and cancer human health effects that are relevant to assessing the risks from chronic inhalation exposure to formaldehyde. To facilitate discussion of several scientific issues pertinent to the assessment, EPA convened a state-of-the-science workshop on April 30 and May 1, 2014. This workshop focused on the following three themes:
- Evidence pertaining to the influence of formaldehyde that is produced endogenously (by the body during normal biological processes) on the toxicity of inhaled formaldehyde, and implications for the health assessment;
- Mechanistic evidence relevant to formaldehyde inhalation exposure and lymphohematopoietic cancers (leukemia and lymphomas); and
- Epidemiological research examining the potential association between formaldehyde exposure and lymphohematopoietic cancers (leukemia and lymphomas).
U.S. EPA. IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/002A, 2010.
The draft toxicological review of formaldehyde - inhalation assessment provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic inhalation exposure to formaldehyde. Formaldehyde is present in a wide variety of products including some plywood adhesives, abrasive materials, insulation, insecticides and embalming fluids. The major sources of anthropogenic emissions of formaldehyde are motor vehicle exhaust, power plants, manufacturing plants that produce or use formaldehyde or substances that contain it (i.e. glues), petroleum refineries, coking operations, incinerating, wood burning and tobacco smoke.
|Sep 1990||The oral RfD for formaldehyde was posted to the IRIS database.|
|May 1991||The cancer assessment for formaldehyde was posted to the IRIS database.|
|Jan 1998||EPA begins the formaldehyde reassessment under the IRIS Program.|
|May 2010||EPA initiated an interagency science consultation on the review of the draft Toxicological Review of formaldehyde.|
|Jun 2010||EPA released an external review draft of the formaldehyde reassessment for public review and comment. Also released was the interagency review draft with comments.|
|Jun 2010||National Academy of Sciences (NAS) conducted an external peer review meeting to review the draft document on Jun 7-8, 2010 in Washington DC.|
|Jul 2010||NAS held their second external review meeting to discuss the draft report on July 6, 2010.|
|Aug 2010||NAS held their third external review meeting to discuss the draft report on Aug 9-10, 2010 in Washington, DC.|
|Oct 2010||NAS held their fourth external review meeting to discuss the draft report on Oct 12-13, 2010 in Washington, DC.|
|Dec 2010||NAS held their fifth and final external review meeting to discuss the draft report on Dec 13-14, 2010 in Los Angelos, CA.|
|May 2011||NAS's Board on Environmental Studies and Toxicology (BEST) releases the NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report).|
|Apr 2014||EPA convened a state-of-the-science workshop on formaldehyde on April 30 and May 1, 2014 in Arlington, VA. This workshop focused on 3 themes, see the web site for specific details.|
Concluding the public review and comment period, public listening session, and NAS independent scientific peer review, the draft Toxicological Review will be revised and will then be submitted for a final Internal EPA review and an EPA-led Interagency Science Discussion. As a last step, the final assessment will be posted on the IRIS database.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.