US EPA

On September 29, 2009, the IRIS Summary and Toxicological Review of Cerium Oxide and Cerium Compounds was finalized and loaded onto the IRIS database. The Toxicological Review of Cerium Oxide and Cerium Compounds was reviewed internally by EPA, by other federal agencies and White House Offices, by expert external peer reviewers, and by the public. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency draft of the Cerium Oxide and Cerium Compounds IRIS assessment are posted on this site.

U.S. EPA. IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (Interagency Science Discussion Draft) . U.S. Environmental Protection Agency, Washington, D.C., 2009.

The draft Toxicological Review of Cerium Oxide and Cerium Compounds provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to cerium oxide and cerium compounds. In addition to serving as a fuel-borne additive, cerium is used as a polishing agent for glass mirrors, plate glass, television tubes, ophthalmic lenses, and precision optics; as a glass constituent to prevent solarization and discoloration; and as a catalyst for automobile emission control systems. The Office of Air and Radiation (OAR), Office of Transportation and Air Quality (OTAQ), has received applications for the registration of fuel-borne additives containing cerium.

This assessment contains the derivation of a chronic reference concentration, as well as a cancer characterization.

Date	Description
01-2005	EPA began developing the Toxicological Review of cerium oxide and cerium compounds.
02-May 2008	EPA released an External Review Draft for public comment and review.
03-May 2008	EPA announced the external peer review panel meeting in a May 6, 2008, Federal Register Notice.
04-Sep 2009	EPA hosted an interagency science discussion on the draft IRIS Summary and Toxicological Review of Cerium Oxide and Cerium Compounds. These comments are provided on this web site.
05-Sep 2009	EPA released the Final Toxicological Review (PDF) and accompanying Summary for Cerium Oxide and Cerium Compounds to the IRIS Web site.

The assessment has been finalized and loaded onto the IRIS database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Toxicological Review of Cerium Oxide and Cerium Compounds (Interagency Science Discussion Draft) (PDF)  (116 pp, 663 KB, about PDF)
• IRIS Summary for Cerium Oxide and Cerium Compounds (Interagency Science Discussion Draft) (PDF)  (16 pp, 177 KB, about PDF)
• OMB Comments IRIS Summary and Toxicological Review of [cerium Oxide and Cerium Compounds (Interagency Science Discussion Drafts) (PDF)  (2 pp, 16 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

• IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft)