US EPA

The Integrated Risk Information System (IRIS) is a U.S. Environmental Protection Agency (EPA) database that contains information on human health effects that may result from exposure to chemical substances in the environment. IRIS is maintained by EPA’s Office of Research and Development.

The IRIS process consists of development of a draft Toxicological Review for the chemical, internal and external scientific reviews of the draft document, EPA responses to review comments, and development and posting on the IRIS web site of an IRIS Summary and final Toxicological Review. EPA is announcing revisions to the IRIS process. New steps in the process include increased participation by other federal agencies and the public in the development of the Toxicological Review and opportunities for other federal agencies to conduct research to fill data gaps.

• Implementation of Revised IRIS Process Memo: Marcus Peacock, EPA Deputy Administrator (PDF)  (11 pp, 256 KB, about PDF)
• EPA's Integrated Risk Information System: Assessment Development Process (2008) (PDF)  (9 pp, 65 KB, about PDF)
• IRIS Process Flow Chart (PDF)  (1 pp, 185 KB, about PDF)
• Revised IRIS Process Question & Answers (PDF)  (5 pp, 26 KB, about PDF)
• Link to the April 10, 2008 Press Release Notice

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

• IRIS Process (Current)
• IRIS Process (2009 Update)
• IRIS Process (2004-2008)
• IRIS Process (Pre-2004)