US EPA

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of chloroprene that will appear on the Integrated Risk Information System (IRIS) database.

U.S. EPA. IRIS Toxicological Review of Chloroprene (2000 External Review Draft). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, NCEA-S-0932, 2000.

The draft Toxicological Review of chloroprene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to chloroprene. Chloroprene (C4H5Cl) is a volatile, flammable liquid used primarily in the manufacture of polychloroprene or neoprene rubber. The latter is used to make diverse products, such as tires, wire coatings, and tubing. Human health risk concerns for chloroprene are primarily related to exposures via effluent and emissions from facilities that use chloroprene to produce polychloroprene elastomers or transport the product, although these exposure concerns have not been well characterized.

Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

• Toxicological Review of Chloroprene (External Review Draft) (PDF)  (66 pp, 267 KB, about PDF)
• IRIS Summary of Toxicological Review of Chloroprene (PDF)  (12 pp, 47 KB, about PDF)
• Charge to Reviewers (PDF)  (2 pp, 12 KB, about PDF)

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