CASRN 7664-41-7

IRIS Toxicological Review of Ammonia (External Review Draft)

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EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ammonia that will appear in the Integrated Risk Information System (IRIS) database.


U.S. EPA. IRIS Toxicological Review of Ammonia (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/013A, 2012.

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About 80% of commercially produced ammonia is used in agricultural fertilizers. Ammonia is also used as a corrosion inhibitor, in water purification, as a household cleaner, as an antimicrobial agent in food products, as a refrigerant, as a stabilizer in the rubber industry, as a source of hydrogen in the hydrogenation of fats and oils, and as a chemical intermediate in the production of pharmaceuticals, explosives, and other chemicals. Ammonia is also used to reduce nitrogen oxide emissions from combustion sources such as industrial and municipal boilers, power generators, and diesel engines. Ammonia is a component of the global nitrogen cycle and is essential to many biologic processes.


Date Description
01-May 1991The RfC for ammonia was posted to the IRIS database.
07-Mar 2012EPA hosted an interagency science consultation meeting on the review of the draft Toxicological Review of Ammonia.
08-Jun 2012EPA released the external review draft of the ammonia assessment for public review and comment. [Federal Register Notice Jun 8, 2012]


Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

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