1,4-Dioxane
CASRN 123-91-1
- Toxicological Review (PDF) (419 pp, 3.69 M)
- IRIS Summary (PDF) (32 pp, 291 K)
IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010
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Overview
Citation
U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010. U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/005D, 2010.
Background
The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.
History/Chronology
Date | Description |
---|---|
Aug 1988 | EPA released the assessment for 1,4-Dioxane. |
Oct 2003 | The IRIS reassessment of 1,4-dioxane was started. |
May 2009 | EPA released an external review draft for public review and comment. |
Sep 2009 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane. |
Aug 2010 | EPA releases the final assessment and the interagency review draft with comments. |
Status
Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.
Download(s)
- Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) (PDF) (298 pp, 3 MB, about PDF)
- 1,4-Dioxane Summary (Interagency Science Discussion Draft) (PDF) (18 pp, 150 KB, about PDF)
- DoD Comments on 1,4-Dioxane (PDF) (5 pp, 38 KB, about PDF)
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