Health Assessment Document for 1,3-Butadiene (External Review Draft)
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The best estimate of human lifetime extra cancer risk from chronic exposure to 1,3-butadiene is 9 X 10-3 per ppm based on a linear extrapolation of the increased leukemia risks observed in occupationally exposed workers. The corresponding estimate of the chronic exposure level of 1,3-butadiene resulting in an extra cancer risk of 10-6 (i.e., one in a million) is 0.1 ppb.
1,3-Butadiene also causes a variety of reproductive and developmental effects in mice and rats; no human data on these effects are available. There are insufficient data from which to draw any conclusions on potentially sensitive subpopulations.
Koppikar, A. Health Assessment Document for 1,3-Butadiene (External Review Draft). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, NCEA-W-0267, 1998.
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