Silver

CASRN 7440-22-4

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 120 K) last updated: 12/01/1991

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
5 x10-3 Dermal Argyria LOAEL : 1.4 x10-2
mg/kg-day
3 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 120 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (14 pp, 120 K) last updated: 06/01/1989

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • In animals, local sarcomas have been induced after implantation of foils and discs of silver. However, the interpretation of these findings has been questioned due to the phenomenon of solid-state carcinogenesis in which even insoluble solids such as plastic have been shown to result in local fibrosarcomas.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 120 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 120 K)

Not assessed under the IRIS Program.

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