IRIS

Apollo

CASRN 74115-24-5

Health Hazard Assessments for Effects Other than Cancer

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 108 K) last updated: 01/31/1987

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Endocrine, Hepatic 1.3 x 10-2 Liver effects; organ weight changes NOEL : 1.25
mg/kg-day
100 High
Endocrine, Hepatic 1.3 x 10-2 Liver effects; organ weight changes NOEL : 1.25
mg/kg-day
100 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 108 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 108 K) last updated: 06/01/1991

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on an increase in thyroid gland follicular cell tumors in male rats and supportive findings in pituitary/thyroid hormone activity.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 108 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 108 K)

Not assessed under the IRIS Program.

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