Metolachlor

CASRN 51218-45-2

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 116 K) last updated: 10/01/1990

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
1.5 x10-1 Reproductive, Other Decreased body weight gain, decreased pup weight and parental food consumption NOEL : 1.5 x101
mg/kg-day
100 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 116 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (12 pp, 116 K) last updated: 08/22/1988

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Classification is based on the appearance of proliferative liver lesions (combined neoplastic nodules and carcinomas) at highest dose tested (3000 ppm) in female rats.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 116 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 116 K)

Not assessed under the IRIS Program.

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