IRIS

Metolachlor

CASRN 51218-45-2

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 116 K) last updated: 10/01/1990

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Reproductive, Other 1.5 x 10-1 Decreased body weight gain, decreased pup weight and parental food consumption NOEL : 1.5 x 101
mg/kg-day
100 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 116 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 116 K) last updated: 08/22/1988

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Classification is based on the appearance of proliferative liver lesions (combined neoplastic nodules and carcinomas) at highest dose tested (3000 ppm) in female rats.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 116 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 116 K)

Not assessed under the IRIS Program.

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