IRIS

Methyl ethyl ketone (MEK)

CASRN 78-93-3

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 211 K) last updated: 09/26/2003

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Developmental 6 x 10-1 Decreased pup body weight LED5 : 639
mg/kg-day
1000 Low

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 211 K) last updated: 09/26/2003

System RfC (mg/m3) Basis PoD Composite UF Confidence
Developmental, Musculoskeletal 5 Developmental toxicity (skeletal variations) LEC (HEC): 1517
mg/m3
300 Medium
Developmental, Musculoskeletal 5 Developmental toxicity (skeletal variations) LEC (HEC): 1517
mg/m3
300 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (33 pp, 211 K) last updated: 09/26/2003

WOE Characterization Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)
Basis:
  • Under the draft revised guidelines for carcinogen risk assessment (U.S. EPA, 1999), EPA concludes the data are inadequate for an assessment of human carcinogenic potential of MEK. Studies of humans chronically exposed to MEK are inconclusive, and MEK has not been tested for carcinogenicity in animals by the oral or inhalation routes.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 211 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 211 K)

Not assessed under the IRIS Program.

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