Methyl ethyl ketone (MEK)

CASRN 78-93-3

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 211 K) last updated: 09/26/2003

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
6 x10-1 Developmental Decreased pup body weight LED5 : 639
mg/kg-day
1000 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 211 K) last updated: 09/26/2003

RfC (mg/m3) System Basis PoD Composite UF Confidence
5 Developmental, Musculoskeletal Developmental toxicity (skeletal variations) LEC (HEC): 1517
mg/m3
300 Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (33 pp, 211 K) last updated: 09/26/2003

WOE Characterization Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)
Basis:
  • Under the draft revised guidelines for carcinogen risk assessment (U.S. EPA, 1999), EPA concludes the data are inadequate for an assessment of human carcinogenic potential of MEK. Studies of humans chronically exposed to MEK are inconclusive, and MEK has not been tested for carcinogenicity in animals by the oral or inhalation routes.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 211 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 211 K)

Not assessed under the IRIS Program.

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