Dichloromethane

CASRN 75-09-2

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (44 pp, 337 K) last updated: 11/18/2011

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
6 x10-3 Hepatic Hepatic effects (hepatic vacuolation, liver foci) BMDL10 (HED): 0.19
mg/kg-day
30 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (44 pp, 337 K) last updated: 11/18/2011

RfC (mg/m3) System Basis PoD Composite UF Confidence
6 x10-1 Hepatic Hepatic effects (hepatic vacuolation) BMDL10 (HEC): 17.2
mg/m3
30 Medium/High

Cancer Assessment


Weight of Evidence for Cancer (PDF) (44 pp, 337 K) last updated: 11/18/2011

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Following U.S. EPA (2005a) Guidelines for Carcinogen Risk Assessment, dichloromethane is "likely to be carcinogenic in humans," based predominantly on evidence of carcinogenicity at two sites in 2-year bioassays in male and female B6C3F1 mice (liver and lung tumors) with inhalation exposure (NTP, 1986) and at one site in male B6C3F1 mice (liver tumors) with drinking water exposure (Serota et al., 1986b Hazleton Laboratories, 1983).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (44 pp, 337 K)

Oral Slope Factor: 2 x10 -3 per mg/kg-day
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMDL10).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas or adenomas (Serota et al. (1986b))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (44 pp, 337 K)

Inhalation Unit Risk: 1 x10 -8 per µg/m3
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMDL10).
Tumor site(s): Hepatic, Respiratory
Tumor type(s): Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas (Mennear et al. (1988), NTP (1986))


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