Dichloroacetic acid

CASRN 79-43-6

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (40 pp, 324 K) last updated: 09/11/2003

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
4 x10-3 Nervous, Reproductive, Hepatic Lesions observed in the testes, cerebrum, cerebellum, and liver. LOAEL : 12.5
mg/kg-day
3000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (40 pp, 324 K) last updated: 09/11/2003
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (40 pp, 324 K) last updated: 09/11/2003

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)
Basis:
  • EPA believes that DCA is likely to be a carcinogen in humans.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (40 pp, 324 K)

Oral Slope Factor: 5 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 1.4 x10 -6 per µg/L
Extrapolation Method: Multistage model with Benchmark Dose Modeling
Tumor site(s): Hepatic
Tumor type(s): Hepatoadenoma and Hepatocarcinoma (DeAngelo et. al., 1999)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (40 pp, 324 K)

Information reviewed but value not estimated.

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