Monochloramine

CASRN 10599-90-3

  • IRIS Summary (PDF) (19 pp, 149 K)
  • Status: Monochloramine is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (19 pp, 149 K) last updated: 03/01/1994

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
1 x10-1 None No observed effects NOAEL : 9.5
mg/kg-day
100 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (19 pp, 149 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (19 pp, 149 K) last updated: 12/01/1993

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on inadequate human data and equivocal evidence of carcinogenicity from animal bioassays. A 2-year bioassay showed a marginal increase in mononuclear cell leukemia in female F344/N rats. No evidence of carcinogenic activity was reported in male rats or in male or female B6C3F1 mice. Genotoxicity studies, both in vitro and in vivo, gave negative results.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (19 pp, 149 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (19 pp, 149 K)

Not assessed under the IRIS Program.

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.