IRIS

Glyphosate

CASRN 1071-83-6

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 102 K) last updated: 01/31/1987

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Developmental, Urinary 1 x 10-1 Increased incidence of renal tubular dilation in F3b offspring NOEL : 1.0 x 101
mg/kg-day
100 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 102 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (10 pp, 102 K) last updated: 10/01/1989

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Inadequate evidence for oncogenicity in animals. Glyphosate was originally classified as C, possible human carcinogen, on the basis of increased incidence of renal tumors in mice. Following independent review of the slides the classification was changed to D on the basis of a lack of statistical significance and uncertainty as to a treatment-related effect.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 102 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 102 K)

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites, including the following:
  • Human Health Benchmarks for Pesticides (HHBP) information. The HHBP website provides toxicity reference values for a number of pesticides to help determine if there is a potential health risk when pesticides are detected in water. However, the toxicity information from the HHBP table may be useful for other purposes.
  • EPA Pesticide Program toxicity information. This link provides information from EPA's Pesticide Program on the derivation of toxicity reference values.
  • EPA's Chemistry Dashboard. This link provides information from EPA's National Center for Computational Toxicology (NCCT) on chemical structures, experimental and predicted physicochemical and toxicity data, and additional links to relevant websites and applications.
  • Contact us about pesticides

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