IRIS

Methyl tert-butyl ether (MTBE)

CASRN 1634-04-4

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (25 pp, 170 K)
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (25 pp, 170 K) last updated: 09/01/1993

System RfC (mg/m3) Basis PoD Composite UF Confidence
Hepatic, Urinary, Ocular, Other 3 Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females) NOAEL (HEC): 2.59 x 102
mg/m3
100 Medium
Hepatic, Urinary, Ocular, Other 3 Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females) NOAEL (HEC): 2.59 x 102
mg/m3
100 Medium
Hepatic, Urinary, Ocular, Other 3 Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females) NOAEL (HEC): 2.59 x 102
mg/m3
100 Medium
Hepatic, Urinary, Ocular, Other 3 Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females) NOAEL (HEC): 2.59 x 102
mg/m3
100 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (25 pp, 170 K)
Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (25 pp, 170 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (25 pp, 170 K)

Not assessed under the IRIS Program.

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