Ethylbenzene
CASRN 100-41-4 | DTXSID3020596
- IRIS Summary (PDF) (21 pp, 148 K)
- Status: Ethylbenzene is in step 1 at this time; see Quick Check.
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (21 pp, 148 K)
Last Updated: 01/31/1987
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic, Urinary | 1 x 10-1 | Liver and kidney toxicity |
NOEL
: 9.71 x 101 mg/kg-day |
1000 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (21 pp, 148 K)
Last Updated: 03/01/1991
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 1 | Developmental toxicity |
NOAEL
(HEC): 4.34 x 102 mg/m3 |
300 | Low |
Cancer Assessment
Weight of Evidence for Cancer (PDF) (21 pp, 148 K)
Last Updated: 09/17/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Nonclassifiable due to lack of animal bioassays and human studies.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (21 pp, 148 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (21 pp, 148 K)
Not assessed under the IRIS Program.
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Ethylbenzene is being reassessed.
Assessment Manager(s): Andrew Kraft (kraft.andrew@epa.gov), Dahnish Shams (shams.dahnish@epa.gov)
| Step | Assessment Materials Released to the Public | Release Date | Public Meeting Date |
|---|---|---|---|
| 1 | Problem Formulation Materials | 09/2017 | 09/2017 |
| 1 | Preliminary Assessment Materials | 02/2023 | N/A |
| 4 | Public Comment Draft | TBD | TBD |
| 4 | Peer Review Draft | TBD | TBD |
| 7 | Post Final Assessment | TBD |
Please note: Any future dates displayed under Release Date are estimates and subject to change.
Feb 2023: Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) (Report)
Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)
Sep 2017: IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials) (Report)
Jul 2014: IRIS Toxicological Review of Ethylbenzene (Scoping and Problem Formulation Materials) (Report)
Mar 1985: Drinking Water Criteria Document For Ethylbenzene (Final Draft, 1985) (Report)
Sep 1984: Health Effects Assessment for Ethylbenzene (Report)
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Quick Check
Critical Effect Systems
Chemical Structure for
Ethylbenzene
