IRIS

Epichlorohydrin

CASRN 106-89-8

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (24 pp, 167 K) last updated: 04/01/1992
Information reviewed but value not estimated.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (24 pp, 167 K) last updated: 04/01/1992

System RfC (mg/m3) Basis PoD Composite UF Confidence
Respiratory 1 x 10-3 Changes in the nasal turbinates NOAEL (HEC): 3.6 x 10-1
mg/m3
300 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (24 pp, 167 K) last updated: 03/01/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Human data are inadequate. Multiple studies in rats and mice administered epichlorohydrin by various routes were positive. As epichlorohydrin is a strong alkylating agent, tumors are produced at the site of application.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (24 pp, 167 K)

Oral Slope Factor: 9.9 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.8 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Papillomas and carcinomas of the forestomach (Konishi et al., 1980)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (24 pp, 167 K)

Inhalation Unit Risk: 1.2 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Nasal cavity tumors (Laskin et al., 1980)


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