Aramite

CASRN 140-57-8

  • IRIS Summary (PDF) (14 pp, 125 K)
  • Status: Aramite is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 125 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 125 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (14 pp, 125 K) last updated: 06/01/1991

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on no human data and sufficient data from animal bioassays including increased incidence of liver tumors and/or neoplastic nodules in three strains of male and female rats and males of one strain of mice, and extrahepatic biliary system tumors in dogs following chronic oral exposure.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 125 K)

Oral Slope Factor: 2.5 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 7.1 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Neoplastic liver nodules and carcinomas (Popper et al., 1960; Oser and Oser, 1962)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 125 K)

Inhalation Unit Risk: 7.1 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Neoplastic liver nodules and carcinomas (Popper et al., 1960; Oser and Oser, 1962)


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