IRIS

Zinc and Compounds

CASRN 7440-66-6

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (21 pp, 154 K) last updated: 08/03/2005

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Immune, Hematologic 3 x 10-1 Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers LOAEL : 0.91
mg/kg-day
3 Medium/High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (21 pp, 154 K) last updated: 08/03/2005
Information reviewed but value not estimated.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (21 pp, 154 K) last updated: 08/03/2005

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Data are inadequate for an assessment of human carcinogenic potential Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess carcinogenic potential of zinc, because studies of humans occupationally-exposed to zinc are inadequate or inconclusive, adequate animal bioassays of the possible carcinogenicity of zinc are not available, and results of genotoxic tests of zinc have been equivocal.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (21 pp, 154 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (21 pp, 154 K)

Not assessed under the IRIS Program.

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