Zinc and Compounds
CASRN 7440-66-6 | DTXSID7035012
- Toxicological Review (PDF) (83 pp, 520 K)
- IRIS Summary (PDF) (21 pp, 154 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (21 pp, 154 K)
Last Updated: 08/03/2005
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Immune, Hematologic | 3 x 10-1 | Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers |
LOAEL
: 0.91 mg/kg-day |
3 | Medium/High |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (21 pp, 154 K)
Last Updated: 08/03/2005
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF) (21 pp, 154 K)
Last Updated: 08/03/2005
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
| Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) | |
| Data are inadequate for an assessment of human carcinogenic potential | Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999) |
| Inadequate information to assess carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess carcinogenic potential of zinc, because studies of humans occupationally-exposed to zinc are inadequate or inconclusive, adequate animal bioassays of the possible carcinogenicity of zinc are not available, and results of genotoxic tests of zinc have been equivocal.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (21 pp, 154 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (21 pp, 154 K)
Not assessed under the IRIS Program.
Additional EPA toxicity information may be available by visiting the following sites:
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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Critical Effect Systems
Chemical Structure for
Zinc and Compounds
