IRIS

Chlorobenzene

CASRN 108-90-7

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 114 K) last updated: 08/01/1989

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic 2 x 10-2 Histopathologic changes in liver NOAEL : 1.9 x 101
mg/kg-day
1000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 114 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 114 K) last updated: 11/01/1990

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • No human data, inadequate animal data and predominantly negative genetic toxicity data in bacterial, yeast, and mouse lymphoma cells.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 114 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 114 K)

Not assessed under the IRIS Program.

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