IRIS

2,4-/2,6-Dinitrotoluene mixture

CASRN NA

Health Hazard Assessments for Effects Other than Cancer

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 110 K)
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 110 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 110 K) last updated: 09/01/1990

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on multiple benign and malignant tumor types at multiple sites in both sexes of rats (2 strains) and malignant renal tumors in male mice. The classification is supported by evidence of mutagenicity.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 110 K)

Oral Slope Factor: 6.8 x10 -1 per mg/kg-day
Drinking Water Unit Risk: 1.9 x10 -5 per µg/L
Extrapolation Method: Linearized multistage procedure
Tumor site(s): Reproductive, Hepatic
Tumor type(s): Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas (Ellis et al., 1979)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 110 K)

Not Assessed under the IRIS Program.

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