Benzyl chloride

CASRN 100-44-7

  • IRIS Summary (PDF) (13 pp, 118 K)
  • Status: Benzyl chloride is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 118 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 118 K) last updated: 01/01/1992
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (13 pp, 118 K) last updated: 08/01/1989

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on inadequate human data and sufficient evidence of carcinogenicity in animals; namely significantly increased incidences of benign and malignant tumors at multiple sites in both sexes of mice and a significant increase in thyroid tumors in female rats. There was evidence of mutagenicity in a variety of test systems.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 118 K)

Oral Slope Factor: 1.7 x10 -1 per mg/kg-day
Drinking Water Unit Risk: 4.9 x10 -6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Endocrine
Tumor type(s): Thyroid, C-cell adenoma/ carcinoma (Lijinsky, 1986)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 118 K)

Not Assessed under the IRIS Program.

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