4,4'-Methylene bis(N,N'-dimethyl)aniline

CASRN 101-61-1

  • IRIS Summary (PDF) (10 pp, 104 K)
  • Status: 4,4'-Methylene bis(N,N'-dimethyl)aniline is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 104 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 104 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (10 pp, 104 K) last updated: 08/01/1989

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Sufficient evidence from animal experiments: thyroid tumors in male and female rats, and liver carcinoma/adenoma in the female mice with a significant positive trend in male mice. There is evidence of mutagenic activity. There are no human data.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 104 K)

Oral Slope Factor: 4.6 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 1.3 x10 -6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Endocrine
Tumor type(s): Thyroid, follicular cell carcinoma/ adenoma (NCI, 1979a)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 104 K)

Not Assessed under the IRIS Program.

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