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- IRIS Summary (PDF) (13 pp, 114 K)
- Status: Prochloraz is not being reassessed by IRIS at this time.
Health Hazard Assessments for Effects Other than Cancer
Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 114 K)
last updated: 01/01/1989
Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 114 K)
Not assessed under the IRIS Program.
Weight of Evidence for Cancer (PDF) (13 pp, 114 K)
last updated: 10/01/1989
|WOE Characterization||Framework for WOE Characterization|
|C (Possible human carcinogen)||Guidelines for Carcinogen Risk Assessment (US EPA, 1986)|
- Statistically significantly increased incidence and dose-related trend in liver adenomas and carcinomas (combined) in both sexes of one strain of mouse.
- This may be a synopsis of the full weight-of-evidence narrative.
Oral Slope Factor:
1.5 x10 -1 per mg/kg-day
Drinking Water Unit Risk: 4.3 x10 -6 per µg/L
Extrapolation Method: Male mice: time-to-tumor linearized multistage procedure in dose, Weibull in time. Female mice: linearized multistage procedure
Tumor site(s): Hepatic
Tumor type(s): Liver adenoma/ carcinoma combined (Nor-Am Chemical Co., 1983)
Not Assessed under the IRIS Program.
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