Bis(chloromethyl)ether (BCME)

CASRN 542-88-1

  • IRIS Summary (PDF) (12 pp, 113 K)
  • Status: Bis(chloromethyl)ether (BCME) is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 113 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 113 K) last updated: 07/01/1991
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (12 pp, 113 K) last updated: 09/26/1988

WOE Characterization Framework for WOE Characterization
A (Human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Statistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 113 K)

Oral Slope Factor: 2.2 x10 2 per mg/kg-day
Drinking Water Unit Risk: 6.2 x10 -3 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 113 K)

Inhalation Unit Risk: 6.2 x10 -2 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)


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